Book through our site
—up to 10% cheaper
than Booking.com
Check rooms and rates
From74US$ /night
Check-in
12Dec2025Select date
Check-out
13Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

220 South Interstate Dr, Sikeston, Missouri, United States, 63801
-
Near the Sikeston Depot Museum & Gallery
Perfect
7.1
7.2
/10
3.1
3.3
/5

Rooms

Days Inn and Suites by Wyndham Sikeston offers spacious suites with separate living rooms. Each suite includes a desk, cable TV, microwave, and mini-refrigerator for convenience. Guests can also choose a pet-friendly room for an additional fee.

Dining

The hotel provides a complimentary light breakfast to start the day. Guests can enjoy their choice of coffee, tea, and juice with breakfast. This offering supports an energized morning before heading out to explore or work.

Location

Located in Sikeston, the hotel is near the Sikeston Rodeo Grounds, known for hosting Missouri's largest rodeo every August. Antique stores and the Cotton Country Mural are a short drive away for those interested in local history. The hotel is positioned midway between St. Louis and Memphis for easy access to both cities.

Business and Events

The hotel includes 5,500 square feet of event space suitable for meetings and social events. Two meeting rooms accommodate up to 80 conference guests or 100 banquet guests. Great rates for groups of all sizes are available when booking events.

Amenities

A fitness center and business center help guests stay productive during their stay. Free parking is provided for vehicles of all sizes, along with guest laundry facilities. Barbecue grills are available for those looking to enjoy outdoor cooking.

Highlights

Location: Near Sikeston Rodeo Grounds

Dining: Free light breakfast

Rooms: Spacious suites with separate living rooms

Business: 5,500 square feet of event space

“Days Inn And Suites By Wyndham Sikeston presents an interesting layout, formerly a retirement community, now offering spacious suite-style rooms. I noted some cleanliness issues during my exploration of the available information and read about inconsistent experiences. For travellers prioritizing space and a unique building conversion over modern polish, this could be a reasonable option.”
Hotel logo
James DavidEditor-in-Chief at Cheaphotels
View all

Select your room type

The hotel provides a selection of rooms—doubles, family rooms, and suites—with perks like free cancellation, breakfast options, and great value deals
One-Bedroom Deluxe King Suite Non-Smoking
2 persons
48 m² 
1 King-size bed
Shower
Coffee machine
One-Bedroom King Suite Non-Smoking
2 persons
48 m² 
Shower
Coffee machine
One-Bedroom Deluxe Queen Suite Non-Smoking
2 persons
48 m² 
2 King Size Beds
Shower
Coffee machine
One-Bedroom Suite Two Queen Beds Non-Smoking
2 persons
48 m² 
Shower
Coffee machine
Click button to see more rooms
Show all rooms
Show all roomsLess

Room rates & availability calendar

See the best prices and book your dates today!

Amenities & services

Real traveler stories and honest reviews—no glossy ads, just authentic feedback to guide your booking

General

  • No smoking on site
  • Free Wi-Fi
  • 24-hour reception
  • Pets allowed
  • Luggage storage
  • Lift
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access
  • Key access

Sports & Fitness

  • Fitness centre

Services

  • Housekeeping
  • Laundry
  • Dry cleaning

Business

  • Meeting/ Banquet facilities
  • Fax/Photocopying

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Dressing area
  • Patio

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Parquet floor
Show more

Location

220 South Interstate Dr, Sikeston, Missouri, United States, 63801
Map view
220 South Interstate Dr, Sikeston, Missouri, United States, 63801
Restaurants
McDonald's
360 m
2605 E Malone
Explore Sikeston
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Malco Sikeston Cinema and Grill
Malco Sikeston Cinema and Grill
10-minute drive
A modern cinema featuring the latest films with comfortable seating and an extensive menu.
Sikeston Depot Museum & Gallery
Sikeston Depot Museum & Gallery
15-minute drive
A historical museum showcasing local history and artifacts, perfect for culture enthusiasts.
Sikeston Sports Complex
10-minute drive
A comprehensive sports facility offering various fields and courts for local games and events.
Golfing at Boot Heel Golf Club
10-minute drive
An 18-hole golf course offering challenges for all skill levels, with rental services available.
Outdoor Fun at Sikeston Sports Complex
10-minute drive
Enjoy various outdoor sports activities, from baseball to walking trails, all in a scenic environment.
McDonald's
McDonald's
5-minute walk
A classic fast-food restaurant known for its burgers and fries, perfect for a quick meal.
Sikeston Diner
10-minute drive
A cozy spot offering traditional American diner food with generous portions and friendly service.
Malco
10-minute drive
A local favorite for catching the newest blockbusters, complete with arcade games and snack options.
Sikeston Sports Complex Events
10-minute drive
Hosts various sports events and competitions throughout the year, great for family outings.
Getting around town
City Centre
Sikeston8 min  ·  5.3 km
Airports
Cape Girardeau Regional Airport (CGI)65 min  ·  43.3 km
Barkley Regional Airport (PAH)132 min  ·  87.6 km
Looking for early-bird discounts?
Get special discounted rates today!
Check Rates
Property information and rules
Check-in
from 15:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Breakfast
A continental breakfast is served and charges are applicable. 
Children & extra beds
There are no extra beds provided in a room.  There are no cots provided in a room. 
Pets
Pets are allowed on request.
Year renovated:
2012
Number of rooms:
60
Former name
Americas Best Value
FAQs
About Days Inn And Suites By Wyndham Sikeston
What is the distance from Days Inn And Suites By Wyndham Sikeston to Cape Girardeau Regional Airport?
The hotel is located 44 km from Cape Girardeau Regional Airport.
What time can I check in and out of Days Inn And Suites By Wyndham Sikeston?
Check-in is at 15:00 and check-out is by 11:00.
What are some nearby restaurants to Days Inn And Suites By Wyndham Sikeston?
Nearby restaurants include Jd's Steakhouse and Saloon, Lamberts Cafe, and El Bracero.
What amenities are available in the rooms at Days Inn And Suites By Wyndham Sikeston?
Rooms feature air conditioning, a flat-screen TV, a refrigerator, a coffee maker, and free toiletries.
Does Days Inn And Suites By Wyndham Sikeston offer breakfast?
The hotel provides a continental breakfast for guests.
What fitness options are available at Days Inn And Suites By Wyndham Sikeston?
The hotel has a fitness center for guest use.
Is parking available at Days Inn And Suites By Wyndham Sikeston?
The hotel offers a car park on-site for guests.
Are pets allowed at Days Inn And Suites By Wyndham Sikeston?
Pets are allowed on request, with additional charges possibly applicable.
What attractions are close to Days Inn And Suites By Wyndham Sikeston?
Attractions such as Sikeston Depot Museum & Gallery (6 km) and Malco Sikeston Cinema and Grill (7 km) are nearby.

Next best alternative

Consider them for your next trip.
Check-in
12Dec2025Select date
Check-out
13Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Need more options?
Check Top hotels near Days Inn And Suites By Wyndham Sikeston
Motel 6-Sikeston, Mo Exterior photo
Mobile-only price

Motel 6-Sikeston, Mo

5.6
Guest rating65 reviews
316m from property
USD 60USD 54
per night
Country Yard Inn Sikeston - Miner Exit 67 On I-55 Beds photo
Mobile-only price

Country Yard Inn Sikeston - Miner Exit 67 On I-55

5.1
Guest rating93 reviews
321m from property
USD 62USD 55
per night
Pear Tree Inn Sikeston Exterior photo
Mobile-only price

Pear Tree Inn Sikeston

9.2
Perfect833 reviews
632m from property
USD 90USD 81
per night